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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Camara Djeneb, Coulibaly Kiyinlma, Yapi Adon Basile*, Bene Kouadio and Zirihi Guédé Noël


In order to detect new plants that can treat toxoplasmosis, we investigated two plants of the Ivorian pharmacopoeia: Ageratum conyzoides and Synedrella nodiflora. Due to their morphological look alike, these two plants are very often confused on the markets by mistaken one for the other in Abidjan. In our study we made a botanical description of each plant, then we compared their cellular toxicity as well as their anti-parasitic activity on Toxoplasma gondii. We noticed that there are significant physiognomic differences between A. conyzoides and S. nodiflora. A. conyzoides is slightly larger than S. nodiflora, and its base is strongly colored in red. The leaves of both plants are approximately the same size and oval shape. The leaves of A. conyzoides are totally toothed and with bristles on both sides, those of S. nodiflora are toothed only on the upper 2/3 and have no bristles on the back. And finally, the flowers of A. conyzoides are white to blue-purple and those of S. nodiflora are yellow. A. conyzoides is not toxic to human HFF cells that do not divide. On the other hand, when the cells are in proliferation, it is found that at concentrations of plant extract ≥ 0.5 mg/ml there is a decrease in cell viability of more than 50%. S. nodiflora has a dose-dependent toxicity on human cells, all HFF cells died at the maximum dose of 1 mg/ml. Due to the toxicity of S. nodiflora on HFF cells, the test on T. gondii tests could not be performed. On the other hand we found that A. conyzoides acts on the parasite with an IC50 of about 0.41 mg/ml. Therefore, by this work, the use of A. conyzoides in traditional medicine is justified with this scientific basis.

Keywords: Antitoxoplasmosis activity, Ethnobotanical surveys, Ivory Coast, Medicinal plants, Toxicity.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database