EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IMPACT OF IL-8 GENE PROMOTER POLYMORPHISM 251T>A IN FAMILY HISTORY AND SEVERITY OF ACNE VALVARIS IN EGYPTIAN PATIENTS

*Talal A. Abd El Raheem, M.D., Nesreen M. Aboraia, M.D., Shereen R. Kaddafy, M.D.,
Noha K. Abdalghafar and Mai Ashraf, M.Sc.

ABSTRACT

Background: Acne vulgaris (AV) is a common multifactorial inflammatory disease of the pilosebaceous unit (PSU) affecting >80% of individuals at some time during their lives. Endogenous as well as exogenous factors underlie the pathogenesis of AV. Genome-wide association studies have shown that genetic factors play an important role in the aetiology and pathogenesis of AV. IL-8 induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection, IL-8 also induces phagocytosis once they have arrived. Aim of the work: This study aimed to detect the functional relationship of IL-8 gene polymorphism with AV and its severity, by detection the association of IL-8-251T>A polymorphism with AV in Egyptian population. Patient and Methods: A total of 200 subjects were analyzed in this case control study. They were divided into two groups: 100 patients with different degrees of AV, and 100 subjects healthy controls. The diagnosis of acne was based on physical examination, and Global Acne Grading System. The genotyping for IL-8 gene was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: Our study showed that AA genotype (mutant genotype) was higher among cases, while TT genotype (wild genotype) was higher among controls with p <0.05. Higher percentage of A- allele (58%) was found among cases, and higher percentage of T- allele (63%) was found among controls with p<0.05. Also our study found that AA genotype was significantly higher among patients with positive family history while TT genotype was significantly higher among patients with negative family history with p = 0.001. And as regards degree of disease severity, higher percentage of severe acne had AA genotype but higher percentage of mild acne had TT genotype with p <0.05. Conclusion: Our study revealed that there is a significant link between IL-8-251T>A single nucleotide polymorphism (SNP) and AV incidence and severity.

Keywords: Acne vulgaris – Interleukin-8 – Polymorphism.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )