MALTODEXTRIN BASED PRONIOSOMES- A PROMISING CARRIER FOR DRUG DELIVERY OF ANTICANCER AGENT

Srikanth*, Anand Kumar Y. and Mallikarjuna Setty C.

ABSTRACT

The aim of this investigation was to prepare and evaluate maltodextrin based proniosomes loaded with capecitabine for improvement in the physical stability and prolong the release time in a controlled manner. Capecitabine proniosomes were prepared by slurry method and further formulations were evaluated for shape, surface morphology, entrapment efficiency and in vitro drug release. The proniosomes were found to be free flowing and uniform coating over maltodextrin powder. The vesicular size of the optimized formulation showed the vesicular size of 3-6μ. The evaluation of entrapment efficiency showed that it played a significant role by varying the concentration of cholesterol and tweens. The highest entrapment efficiency was found in formulation C4 with 62.33 ± 0.34 highest cumulative percent drug release was observed with formulation C3 with 94.58 ± 0.53 in 36h. The results demonstrated that capecitabine loaded proniosomes offers an alternative carrier approach in increasing its physical stability and are capable of releasing the drug for the extended period of time.

Keywords: Capecitabine, Proniosome, Maltodextrin, Tween80, Tween20.