EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

DESIGN, FABRICATION AND EVALUATION OF GEMIFLOXACIN AND AMBROXOL HYDROCHLORIDE SUSTAINED RELEASE TABLETS BY WET GRANULATION TECHNIQUE

Naga Raju Potnuri*, Sneha Aashigari, Sneha Sama, Ramya Goud Gullapalli, Mohd Farathullah Asrari and Snehitha Janjerla

ABSTRACT

The present study aimed to design, fabrication and evaluation of Gemifloxacin and Ambroxol hydrochloride sustained release tablets by using wet granulation technique, to achieve a controlled and sustained drug release with reduced frequency of drug administration, reduced side effects and improved patient compliance. Gemifloxacin and Ambroxol Hcl sustained release tablets were prepared by using natural polymer like Guar gum and Xanthan gum. All the batches (F1-F9) were evaluated for pre compression parameters, post compression parameters and in vitro drug release characteristics. The drug release rates from tablets were compared with marketed formulations. The release kinetics and mechanism of drug release by regression coefficient analysis, higuchi constant and peppas exponential release model equations were also investigated. The Gemifloxacin and Ambroxol Hcl released from the tablets follows higuchi diffusion mechanism and Non-Fickian transport system. The interactions between the drug, polymers and adjuvants during the wet granulation technique are also investigated by using FT-IR examination.

Keywords: Gemifloxacin (GFX), Ambroxol Hydrochloride (Ambroxol Hcl), Guar gum, Xanthan gum, Micro Crystalline Cellulose (MCC) and Fourier transform infrared spectroscopy (FT-IR).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia