EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AMELIORATING THE SIDE EFFECTS OF PENICILLIN AND STREPTOMYCIN ON HEPATOCYTES USING VITAMIN C IN GUINEA PIGS

Adel A. A. Muaqeb, Ebtisam Y. Shikoo, Mohammed S. A. Al-Awar* and Amal M. H. Banafa

ABSTRACT

Background: Penicillin and streptomycin have long been used in antibacterial therapy. The effects of penicillin and streptomycin on histological structure of liver are well studied. It has been reported that the effects of aminoglycoside and penicillin mainly due to the generation of an excessive amount of reactive oxygen species (ROS), vit C has the ability to counteract free radicals and protect the structure and function of proteins, DNA and chromosomes against oxidation injury, and they are the most powerful in reducing storage and toxicity of reactive oxygen species. Aim: To investigate ability of Vit C as antioxidant on reducing the side effect of Penicillin and Streptomycin on function and tissue of liver in guinea pig. Methods: A total of fifty-five adult male guinea pigs weighting 800-900g were divided into six groups, and the period of experiment was 30 days. Group I served as control, group 2 were administrated orally with Vit C 100 mg/kg, group 3 were intraperitoneally (i.p.) injected with penicillin 50000 IU/kg, group 4 in addition penicillin (50000IU/kg) were orally administrated with vit C 100 mg/kg, group 5 were (i.p.) injected with streptomycin 50 mg/kg, and group 6 in addition streptomycin (50 mg/kg) were orally administrated with Vit C 100 mg/kg. Results: The result showed a significant increase in the levels of AST, ALT and ALP, and a significant decrease in the levels of total protein and albumin, with histopathological changes in penicillin and streptomycin treated guinea pigs when compared to the control. Administration of vitamin C to penicillin and streptomycin treated groups produced significant (P<0.01) reduction in AST, ALT and ALP and an increase in total protein and albumin levels. Administration of Vit C also decreased these histopathological changes in hepatocytes appearance was more or less similar to control group as well as its function. Conclusion: The present results indicate that Vit C may play an important role as Cytoprotective and pave the way for further studies on the possible use of Vit C.

Keywords: Vitamin C, Penicillin, Streptomycin, Histological and Biochemical study.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )