EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

INFLUENCE OF PSYCHOLOGICAL AND PERSONALITY CHARACTERISTICS OF PATIENTS WITH CORONARY ARTERY DISEASE ON THE PHENOTYPE OF PLATELETS

*Abdumalikova Feruza Bakhtiyarovna and Nurillaeva Nargiza Muhtarkhanovna

ABSTRACT

To assess the influence of psychological distress on the morphological characteristic of the blood platelets depending on the level of anxiety-depressive syndrome in patients with cardiac pathology, examined 112 persons, of whom 84 patients with coronary artery disease, angina pectoris FC II-III, whose age average was 60.9±1.46 years. Assessment of the level of psychoemotional status was conducted using hospital scale of anxiety and depression - HADS. To determine the personality type D was used a questionnaire - DS14. Study of the phenotype of platelets was performed using flow cytometry. The patients were divided into 2 groups: I group (n=40) patients with anxiety-depressive syndrome and the II group (n=44) without anxiety and depression. When assessing the interrelated effects of anxiety-depressive syndrome and psychological distress at the performance of platelet profile in patients, the differences in the groups according to the platelet phenotype. The patients of the I group the average platelet (PLT) made up 312,1±17,17х109/L, while in patients with type D value to PLT averaged 316,7±17,54х109/L, which was dominated by above average PLT-220,4±10,48 х109/L in the II group (p<0,001). The average value of the width of the platelets distribution (PDW) was significantly higher in I group patients at a mean of 17.0±0,94 fL vs 13,6±0,76 fL compared with patients of II group (p<0,05). The average platelet volume (MPV) of the I group on the background of anxiety and depression were statistically significantly prevailed the value MPV, which amounted to an average of 11.3±0,42, in contrast to performance II and control group of 9.7±0,23 and 8.7±0,28 fL, respectively (p<0,001). Increased functional activity of platelets in patients with ischemic heart disease, due to the influence of anxiety and depression associated with personality.

Keywords: coronary artery disease, arterial hypertension, anxiety-depressive syndrome, personality type D, platelets profile, phenotype of blood platelets.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )