SYNTHESIS, CHARATERIZATION AND ANTIINFLAMMATORY, ANTI MICROBIAL AGENTS OF NOVEL QUINAZOLIN-4-(3H)-ONE DERIVATIVES

Kavitha K.*, Srinivasan N., Suresh R., Haribabu Y., Sivakumar T.

ABSTRACT

Some novel 2, 3 substituted Quinazolin-4-(3H)-one were synthesized in good yields and evaluated for their possible anti inflammatory, anti bacterial activities and acute toxicity. The structures of the newly synthesized compounds were confirmed by their spectral data, elemental analysis. Their antibacterial activities were evaluated by agar well diffusion method while their anti-inflammatory activities were evaluated by the Carrageen an induced hind paw edema test. The newly synthesized showed considerable anti bacterial activities and high to moderate anti inflammatory activities when compared to that of indomethacin as standard drug. All the tested compounds showed no toxic symptoms or mortality rates 24 h post-administration at tested anti-inflammatory doses. In addition, LD50 for all tested compounds was higher than that for indomethacin implying their good safety margin. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs.

Keywords: Quinazolinone, benzoxacine 4 one, anti bacterial, anti inflammatory, aniline derivatives.