A STUDY OF SERUM VITAMIN D LEVELS IN PATIENTS WITH HYPOTHYROID

Dr. Shubhi Mishra*, Dr. Sangeeta Kapoor, Dr. V. K. Singh, Sushil Yadav, Fozia Jamal and Jyoti Trivedi

ABSTRACT

Background: Hypothyroidism, also known as underactive thyroid or low thyroid, is a disorder of the endocrine system, which is characterized by reduced production of thyroid hormones by thyroid gland. Hypothyroidism can be primary hypothyroidism or secondary /central hypothyroidism. On the basis of etiology, primary hypothyroidism can be further classified into autoimmune (AITD) and non-autoimmune thyroid diseases (NAITD). vitamin D has an important role in the regulation of Th1 ,Th2 and Th17 cells and it also regulates the secretion of cytoxines IF--, Interleukin-4(IL-4) and IL-17.[24-27] These findings, though not conclusive, suggest the possible role of vitamin D in autoimmune thyroid disorders. Therefore, the present study aimed to study the status of Vitamin D in Hypothyroidism. Material and Methods: In “the present study, 50 hypothyroid patients aged 20 to 50 years were enrolled who were confirmed by the estimation of serum T3, T4 and TSH (>6.16μIU/ml)) level were selected from the OPD of Teerthanker Mahaveer Hospital. The “serum total TSH, T3, T4, TPO-Ab and Vitamin D were estimated by ELFA technique (Enzyme Linked Fluorescent Assay) using fully automated VIDAS analyzer. Observations & Results: Mean levels of serum Vitamin D level in hypothyroid patients was 16.10±10.62 ng/ml, which was statistically lower than that of healthy group with serum Vitamin D level 24.77±16.85 ng/ml (p- value=0.003). Conclusion: Our findings indicate that patients with hypothyroidism suffered from deficiency of vitamin D. Moreover, the negative significant correlation between vitamin D levels and TSH levels, suggested that deficiency of serum vitamin D levels were significantly associated with degree and severity of the hypothyroidism which encourage the advisability of vitamin D supplementation.

Keywords: Vitamin D, Hypothyroidism, Autoimmune thyroid diseases (AITDs).