EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HEPATOBILIARY ABNORMALITIES AMONG PEOPLE LIVING WITH HIV/AIDS IN SOUTHERN ODISHA

Sethy Ganeswar, Omen Thomas Abel, Sethy Geetanjali*, Dr. Arakhita Swain and
Dr. Saiprasanna Behera

ABSTRACT

Background: Southern Odisha has nearly 40% of total PLHAs (People Living with HIV/AIDS) of the state.Aims: The aim was to explore theprevalence of Hepatobiliary abnormalities in PLHAs of southern Odisha with periodical follow up over a period of one year and nine months. Settings and Design: Prospective observational study. Materials and Methods: Fifty HIV infected patients enrolled in ART(Antiretroviral Therapy) centre, MKCG Medical College Hospital, Brahmapur, were included and prospectively followed up and analyzed every five monthsfor liver enzymes and total bilirubinfrom January 2015 to September 2016. Results: The prevalence of hepatobiliary abnormalities was found to be 84%. Among the study subjects, 30% had raised aminotransferases, while 54% had isolated elevation of ALP(Alkaline Phosphatase). 20% had jaundice with raised bilirubin. Eight per cent were seropositive for HBsAg (Hepatitis B surface antigen), of which three-fourth had abnormal liver enzymes. Forty four percent were alcoholics; all had hepatobiliary abnormalities and half of them had isolated ALPelevation. Sixty per cent had tuberculosis (with completed DOTS), ofwhich 24% had elevated liver enzymes and 32% had isolated ALP elevation. Conclusions: The prevalence of hepatobiliary involvement in PLHAs is quite high. Multiple factors can be attributed for this. Hence, physicians treating them should be more vigilant for monitoring of hepatotoxicity.

Keywords: Southern Odisha, PLHAs, Hepatobiliary, HIV.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )