HEPATOBILIARY ABNORMALITIES AMONG PEOPLE LIVING WITH HIV/AIDS IN SOUTHERN ODISHA

Sethy Ganeswar, Omen Thomas Abel, Sethy Geetanjali*, Dr. Arakhita Swain and
Dr. Saiprasanna Behera

ABSTRACT

Background: Southern Odisha has nearly 40% of total PLHAs (People Living with HIV/AIDS) of the state.Aims: The aim was to explore theprevalence of Hepatobiliary abnormalities in PLHAs of southern Odisha with periodical follow up over a period of one year and nine months. Settings and Design: Prospective observational study. Materials and Methods: Fifty HIV infected patients enrolled in ART(Antiretroviral Therapy) centre, MKCG Medical College Hospital, Brahmapur, were included and prospectively followed up and analyzed every five monthsfor liver enzymes and total bilirubinfrom January 2015 to September 2016. Results: The prevalence of hepatobiliary abnormalities was found to be 84%. Among the study subjects, 30% had raised aminotransferases, while 54% had isolated elevation of ALP(Alkaline Phosphatase). 20% had jaundice with raised bilirubin. Eight per cent were seropositive for HBsAg (Hepatitis B surface antigen), of which three-fourth had abnormal liver enzymes. Forty four percent were alcoholics; all had hepatobiliary abnormalities and half of them had isolated ALPelevation. Sixty per cent had tuberculosis (with completed DOTS), ofwhich 24% had elevated liver enzymes and 32% had isolated ALP elevation. Conclusions: The prevalence of hepatobiliary involvement in PLHAs is quite high. Multiple factors can be attributed for this. Hence, physicians treating them should be more vigilant for monitoring of hepatotoxicity.

Keywords: Southern Odisha, PLHAs, Hepatobiliary, HIV.