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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Mahmood Khan*, Fayaz Hussain Khoso, Kanchan Devi, Om Parkash, Ravi Kumar, and Akash Mandhan


Background: Chronic liver disease (CLD) is characterized by series of progressive destruction followed by regeneration of liver parenchyma that leads to fibrosis and cirrhosis. Presently, esophagogastroduodenoscopy (EGD) is said to be gold standard test in diagnosis of esophageal Varices (EVs), but it is a highly skillful interventional procedure so needs subjective expertise. In contrast, serum albumin can be useful tool in prediction of esophageal varices. Objective: The aim of this study is to explore the diagnostic efficacy of serum albumin for prediction of esophageal varices in patients suffering from chronic liver disease by taking EGD as gold standard investigation for EVs. Material & Methods: This was a cross sectional study conducted at Department of Medicine, LUMHS Hospital hyderbad/Jamshoro and department of Gastroenterology, AIMS Hospital, Hyderabad from January 2018 to November 2018. The study was designed on non-probability, consecutive sampling technique. Informed written consent was received from all patients. Demographic details (name, gender, age and contact) were also noted. Venous blood sample was taken from all patients by using 5cc disposable syringes. The samples were brought to LUMHS Hospital laboratory for serum albumin levels assessment. The results were assessed and patients were labeled either positive or negative for esophageal varices. EGD was done in all patient by a consultant gastroenterologist. Presence or absence of the varices was noted. 2x2 table was applied to calculate the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of serum albumin levels as compared to known gold standard test esophagogastroduodenoscopy. Results: In this study the mean age of the patients was noted as 53.63±15.32 years. The male to female ratio of the patients noted was 2.3:1. EVs on serum albumin levels were found positive in 39 (41.1%) cases & EGD was found positive in 37 (38.95%) cases. The sensitivity of esophageal varices on serum albumin was 81.1% and specificity 84.5%. The PPV value was 76.9%, NPV value was 87.5% and diagnostic accuracy of esophageal varices on serum albumin was 83.2%. Conclusion: Based on results of this study we are of opinion that serum albumin is a reliable predictor and first line diagnostic tool for esophageal varices development in patients of chronic liver disease.

Keywords: Serum Albumin, Esophageal Varices (EVs), Chronic Liver Disease (CLD), Esophagogastroduodenoscopy (EGD).

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )