COMPARATIVE CYTOTOXICITY ANALYSIS OF EXFOLIATED MUCOSAL EPITHELIAL CELLS IN MAVA, TOBACCO AND PANMASALA CHEWERS
Nikita Vadsaria, Krithika Rajesh and R. J. Verma*
ABSTRACT
The rationale of the present study was to evaluate cytological alterations in panmasala chewers and compare it with other chewing stuff’s such as tobacco and mava chewers. The buccal cytome assay was used to determine nuclear anomalies. The assay was applied to exfoliated buccal mucosal cells of 100 subjects (nonchewers-50 and different groups of chewers-50) having different habits, such as tobacco, mava, panmasala and arecanut chewing. 1000 cells per individual were examined microscopically. The results showed significant difference in cytotoxicity of all the products consumed by people. The mava chewers showed significantly higher anomalies in buccal cells followed by tobacco and panmasala. This might be due to physical damage caused by arecanut and chemical exothermic reaction due to presence of lime; these two processes goes hand in hand which could be potent reason.
Keywords: Mava, panmasala, tobacco, micronucleus, binucleus, karyohexis, karyolysis, pyknotic, fragmented cells.
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