EVALUATION OF ANTI DEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF TALINUM PORTULACIFOLIUMON
B Babu Rao*, V Shashanka and C H. Deepika Reddy
ABSTRACT
The ethanolic extract of The Talinum portulacifolium whole plant used for CNS disorders and pain, in animal models of anxiety and depression-the open field test, the light/dark box, the Elevated plus Maze (EPM), the Forced Swimming Test (FST) and Tail Suspension Test (TST) has been reported. The TPE has the antidepressant activity, depends on the dose, thus in the forced swimming test the TPE-400 group showing the significant antidepressant activity, while the TPE-200 is lacking the significance. The TPE 400 mg/kg had significant antidepressant activity which is lower than the standard drug imipramine 30 mg/kg. TPE 200, TPE-400 groups did not showed any significant in the open field test model. The TPE showed significant enhancement of time spent in open arm aswell open arm crossing after 4 weeks of drug administration. Thus both doses of the methanol extract of Talinum portulacifolium having the chronic effect.TPE200 mgkg showed no significant activity in the tail suspension test where as 400 mg/kg decreased the immobility time in tail suspension test models. Thus the TPE is showing the activity in dose dependent manner.
Keywords: Antidepressant activity, Elevated plus Maze, Forced Swimming Test (FST), Open field Test.
[Full Text Article]
[Download Certificate]