EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

EVALUATION OF ANTI DEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF TALINUM PORTULACIFOLIUMON

B Babu Rao*, V Shashanka and C H. Deepika Reddy

ABSTRACT

The ethanolic extract of The Talinum portulacifolium whole plant used for CNS disorders and pain, in animal models of anxiety and depression-the open field test, the light/dark box, the Elevated plus Maze (EPM), the Forced Swimming Test (FST) and Tail Suspension Test (TST) has been reported. The TPE has the antidepressant activity, depends on the dose, thus in the forced swimming test the TPE-400 group showing the significant antidepressant activity, while the TPE-200 is lacking the significance. The TPE 400 mg/kg had significant antidepressant activity which is lower than the standard drug imipramine 30 mg/kg. TPE 200, TPE-400 groups did not showed any significant in the open field test model. The TPE showed significant enhancement of time spent in open arm aswell open arm crossing after 4 weeks of drug administration. Thus both doses of the methanol extract of Talinum portulacifolium having the chronic effect.TPE200 mgkg showed no significant activity in the tail suspension test where as 400 mg/kg decreased the immobility time in tail suspension test models. Thus the TPE is showing the activity in dose dependent manner.

Keywords: Antidepressant activity, Elevated plus Maze, Forced Swimming Test (FST), Open field Test.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia