ANTICANCER POTENTIAL OF A NOVEL SIDDHA METALLO-MINERAL FORMULATION “KAALAMEGA NARAYANA CHENDHOORAM†AS MENTIONED IN “ATHMARAKSHA MIRTHAM ENNUM VAITHIYA SAARA SANGERAHAM†THROUGH A KB CELL LINE STUDY FOR ORAL CANCER
Dr. R. Abinaya*, Dr. R. Vijaya Nirmala, Dr. R. Karolin Daisy Rani and Dr. M. D. Saravana Devi
ABSTRACT
Aim and Objective: The aim of the present study is to validate the Anti oral cancer potentials of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a KB cell line study. Methods: Cancer is one of the life threatening disease which have been seen frequently in Worlds population. Still modern system of medicine struggled with cancer to find the better treatment and complete cure for cancer without any complications or adverse effects of medicine. The mortality rate of cancer gradually increased day by day. Siddha system of medicine was one of the traditional system of medicine had provide various formulations which were obtained from the nature products gave the fruitful effect on dealing with cancer. Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham, a novel siddha metallo-mineral formulation which has a anticancer potential was underwent globally accepted technique for screening anticancer potentials through MTT assay for KMNC was done on KB cell lines with various concentration of the drug as 6.25 μg/ml, 12.5 μg/ml, 25 μG/ml, 50 μg/ml, 100 μg/ml. Raising the modern medical science to support the effect of heavy metals usage in aspect of cancer treatment. Results: At the end of this preliminary research study, that the trail drug of a novel siddha metallomineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a KB cell line study was found to be a potent anticancer medicine on human oral cancer cells. It showed (IC 50) 50 % inhibitory concentration at 50μg/mL. There has been showed that there was a decrease in a number of cell with increasing the concentration of the drug as 6.25 μg/ml, 12.5 μg/ml, 25 μG/ml, 50 μg/ml, 100 μg/ml showed the percentage of viability as 100%, 96.43%, 87.70%, 75.44%, 53.72%, 43.50.%. Thus the Further studies with the trail medicine KMNC will pave the right path towards the safe and potent as anticancer medicine. Conclusion: The present preliminary in-vitro study of a potent siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a KB cell line study was found to be a potent anticancer medicine on human oral cancer cells.
Keywords: Kaalamega Narayana Chendhooram, KMNC, Chendhooram, Siddha, metallo-mineral formulation, KB cell line, MTT assay, Oral cancer, Cancer.
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