COMPARATIVE STUDY TO EVALUATE THE EFFECTIVENESS OF METFORMIN AND MYOINOSITOL IN THE TREATMENT OF POLYCYSTIC OVARIAN SYNDROME
*Dr. T. Lakshmi Teja, Dr. Y. Rupa, Dr. B. Madhavi and Dr. Ch. Roja
ABSTRACT
Introduction: In polycystic ovary syndrome (PCOS), changes in physical appearance i.e. weight gain, hirsutism, menstrual disturbances and infertility result in reduced quality-of-life. Metformin and Myoinositol being insulin sensitizers improve biochemical, clinical and reproductive parameters in PCOS in women. Objective: This study was done to compare the efficacy and safety of Myoinositol versus Metformin in PCOS in women. Methodology: A prospective observational study was conducted on 60 patients at DURGABAI DESHMUKH HOSPITAL AND RESEARCH CENTRE, HYDERABAD in Department of Gynaecology for a period of six months. Results: There was significant improvement in all the symptoms in both the groups over a period of 6 months. However, on comparing both the groups after 6 months, no significant difference was observed in all the symptoms. Regulation of menstrual cycles was better with Myoinositol as compared to Metformin. Conclusion: Our study was to compare the effectiveness of Myoinositol versus Metformin in PCOS patients. Using clinical assessment, we have shown that Myoinositol and Metformin, both the drugs resulted in significant weight loss, regularization of menses. In women with the PCOS, insulin resistance is related to a deficiency in Myoinositol containing mediator of insulin action and the administration of the Myoinositol improves insulin sensitivity to conclude, Metformin is effective in reducing the metabolic and hormonal parameters and also improves fertility but Myoinositol not only improves all the above parameters but also decreases insulin resistance. Myoinositol also has better patient compliance and well tolerated than Metformin.
Keywords: Myoinositol, Metformin, Hirsutism, Infertility, Polycystic ovarian disease.
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