EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE STUDY TO EVALUATE THE EFFECTIVENESS OF METFORMIN AND MYOINOSITOL IN THE TREATMENT OF POLYCYSTIC OVARIAN SYNDROME

*Dr. T. Lakshmi Teja, Dr. Y. Rupa, Dr. B. Madhavi and Dr. Ch. Roja

ABSTRACT

Introduction: In polycystic ovary syndrome (PCOS), changes in physical appearance i.e. weight gain, hirsutism, menstrual disturbances and infertility result in reduced quality-of-life. Metformin and Myoinositol being insulin sensitizers improve biochemical, clinical and reproductive parameters in PCOS in women. Objective: This study was done to compare the efficacy and safety of Myoinositol versus Metformin in PCOS in women. Methodology: A prospective observational study was conducted on 60 patients at DURGABAI DESHMUKH HOSPITAL AND RESEARCH CENTRE, HYDERABAD in Department of Gynaecology for a period of six months. Results: There was significant improvement in all the symptoms in both the groups over a period of 6 months. However, on comparing both the groups after 6 months, no significant difference was observed in all the symptoms. Regulation of menstrual cycles was better with Myoinositol as compared to Metformin. Conclusion: Our study was to compare the effectiveness of Myoinositol versus Metformin in PCOS patients. Using clinical assessment, we have shown that Myoinositol and Metformin, both the drugs resulted in significant weight loss, regularization of menses. In women with the PCOS, insulin resistance is related to a deficiency in Myoinositol containing mediator of insulin action and the administration of the Myoinositol improves insulin sensitivity to conclude, Metformin is effective in reducing the metabolic and hormonal parameters and also improves fertility but Myoinositol not only improves all the above parameters but also decreases insulin resistance. Myoinositol also has better patient compliance and well tolerated than Metformin.

Keywords: Myoinositol, Metformin, Hirsutism, Infertility, Polycystic ovarian disease.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )