EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF INCREASING BMI ON ENZYMES USED FOR ASSESSMENT OF LIVER FUNCTION

Rangwala Tasneem*, Bafna Angoorbala, Maheshwari R.S, Ajmera Shweta and Batham Anil Rai

ABSTRACT

WHO: Expert Committee Recommended that obesity is emerging as worldwide epidemic. Present study describes the effect of increasing Body Mass Index (BMI) on enzymes used for assessing liver function. This study is based on 50 healthy and 190 obese subjects of age group 20-50 years. Obese subjects were selected on the basis of BMI and were divided into three categories according to BMI viz overweight, obese and morbid obese. These were further divided on the basis of gender. Serum Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) level were estimated. It was observed that serum ALT level of control male was 26.67+6.5IU/L and of control female was 22.73+7.5 IU/L. Serum ALT level in overweight, obese and morbid obese males were 32.73+13.2 (p value<0.10), 1.45+13.5 (p value<0.0005) and 72.19+14.05 IU/L (p value<0.0005) respectively and in overweight, obese and morbid obese females were 43.47+18.33 (p value<0.005), 44.59+12.31 (p value<0.0005) and 72.96+11.2 IU/L (p value<0.0005). Serum AST level in control, overweight, obese and morbid obese males were 12.27+8.17, 15.97+7.46 (p value<0.10), 17.1+8.19 (p value<0.10) and 27.51+7.58IU/L (p value<0.0005) and in females were 18.93+8.65, 20.56+9.52 (p value<0.10), 25.57+12.57 (p value<0.10) and 45.45+7.11IU/L (p value<0.0005) respectively. Thus in females, with increase in BMI the level of ALT also increase eventually. Similarly males also show increased ALT level with increase in BMI. However in overweight males rise in ALT level is not significant. While comparing the AST level it was found that significant variation occur only in morbid obese males and females, which may be due to liver dysfunction.

Keywords: Obesity, Overweight, Morbid Obese, Alanine Aminotransferase, Aspartate Aminotransferase.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database