ANGIOPOIETIN-LIKE 4 (ANGPTL4) AND CANCER
Mohamed Hassam Mohamed* and Fan Yue Zu
ABSTRACT
Angiopoietin-like 4 (ANGPTL4) is one of the many secreted proteins predominantly expressed adipose tissues as well as the liver, and plays a central role in both metabolic and non-metabolic processes including energy homeostasis and angiogenesis. Recently, it is demonstrated that ANGPTL4 is involved in tumorigenesis and progression of human cancers. But, the biological features, roles and mechanisms of ANGPTL4 in the tumorigenesis, development and progression of human cancers aren’t thoroughly elucidated. Therefore, identification of special biological behaviors, further understanding the roles and mechanism of ANGPTL4 in tumorigenesis and development of human cancer is of very significant. This review pays key attention to the physical, chemical and structure of ANGPTL4 and its role in different types of cancers, specially, focuses on the expression of ANGPTL4 in relation to tumorigenesis, development and progression of human cancer.
Keywords: Angiopoietin-like 4: Tumorigenesis: Angiogenesis: Cancer.
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