INACTIVATION OF CU-ZN SUPEROXIDE DISMUTASE OF MYCOBACTERIUM TUBERCULOSIS H37RV

Zahra M. Al-Khafaji*, Aaisha B. Mahmood Marium B. Mahmood

ABSTRACT

Background: Tuberculosis is one of serious disease caused by Mycobacterium tuberculosis which resides in macrophages, where exposed to toxic forms of reactive oxygen intermediates(ROS). The bacteria can overcome the intracellular defenses by producing different types of Superoxide dismutases (SODs), one of them Cu-Zn superoxide dismutase (SODc) with peripheral localization to protect the bacteria against oxidative stress and contributes to its pathogenicity and virulence. Aim: of this study was to find safe new inhibitors to SODc using QSAR modeling (MLR regression). Results: one QSAR model was satisfied the validation criteria, was used to find out new molecules, the latter were checked for different characters, two molecules 5,8-dihydroxy-1H-quinolin-4-one (zinc_34198840 ) and 1,3,6,8-Tetrahydroxynaphthalene ( zinc_901903), were able to dock with the target protein (1PZS) strongly.

Keywords: .