( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Dr. Hanaasha Kumar, Prof. Song Jiquan and Ligi Isac


Objective: A study to evaluate gene polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene C677T that exists in cases with psoriasis in the Chinese Han population with a view to find linkage of risk. Methods: A case control study of 94 individuals were designed. Among them were 44 patients with psoriasis, (40 males and 4 females), and 50 healthy controls. The extraction of genomic DNA of cases and controls were performed and for amplification polymerase chain reaction was used. Single nucleotide polymorphism (SNP) of MTHFR gene (rs1801133) was analysed using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism method (PCR-RFLP). Results: In the present study we had assessed the gene and single nucleotide protein MR - C677T Gene (rs 1801133) and we evaluated that TC type, CC type, TT C type, TT T type were seen in 9 cases, 00 cases, 35 cases, 9 cases and 79 cases respectively. TC type accounts about 20.5% and TT type 79.5% of case controls. The absence of the C allele was seen in 35 cases of psoriasis. All the control displayed the TT allele of MR - C677T Gene (rs 1801133) so P value could not be evaluated. In the present study, we had about 44 patients, on evaluation of the gender, shows a higher incidence of psoriasis in males, with a male to female ratio of 10:1. The age of the individuals in the study ranged between 9 to 86 years. The mean (SD) age is 47.45 (19.97). The mean ±SD PASI score is 10.71±5.91. Conclusion: Polymorphism in the methylenetetrahydrofolate reductase gene (677C>T, rs1801133) has no association with psoriasis in Chinese Han population. Those with extensive form of the disease had no association with polymorphism in the methylenetetrahydrofolate reductase gene (677C>T, rs1801133).

Keywords: Methylenetetrahydrofolate reductase; gene polymorphism; psoriasis; single nucleotide.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )