BRAIN RADIONECROSIS IN PATIENTS IRRADIATED FOR NASOPHARYNGEAL CARCINOMA: ABOUT ONE CASE AND REVIEW OF LITARATURE
Taghzout Hasnae*, Chbihi Hassani Ghita, Hafidi Khaoula, Alami Zineb, Bouhafa Touria and Hassouni Khalid
Cerebral radionecrosis is a rare, late iatrogenic complication that occurs after more than six months from the start of treatment in irradiated patients for undifferentiated nasopharyngeal carcinoma. This could be explained by the conjunction of vascular, glial and immunological lesions. This may involve the patient's functional and vital prognosis. Conventional MRI (Magnetic resonance imaging), coupled with spectroscopic sequences, greatly contributed to the follow-up of irradiated patients to refine the differential diagnosis between tumor recurrence and radionecrosis. Getting histological evidence by surgical excision or stereotactic biopsy remains to be discussed. given the lack of potentially effective treatment prevention through better dosimetric planning is fundamental. We report a case in a patient treated with induction chemotherapy followed by concomitant radiochemotherapy for locally advanced nasopharyngeal cancers. The diagnosis was guided by spectroscopic MRI and the evolution was favorable under steroids.
Keywords: Cerebral radionecrosis, Nasopharyngeal cancers, radiotherapy, Spectroscopic MRI.
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