ANTIHYPERGLYCEMIC POTENTIAL OF LAGHU MALINI VASANTA RASA- ZINC CONTAINING AYURVEDIC HERBOMINERAL PREPARATION.

Walunj Manisha*, Gunjal A,Nariya M, PK Prajapati

ABSTRACT

Context: Laghu Malini Vasanta Rasa is a renowned formulation for its rejuvenation effect. In textual reference of drug, it is not indicated in diabetes per se. As per Ayurvedic treatment protocol for disease, rejuvenation (Dhatu Yapana/ Santarpana) therapy is essential in diabetic patients. This justifies exploit of this particular formulation in management of diabetes traditionally by Ayurveda practitioners. Aims: To evaluate anti hyperglycemic effect of Laghu Malini Vasanta Rasain albino mice. Methods and material: Swiss albino mice of either sex were divided randomly in three groups; control group, Laghu Malini Vasanta Rasa(32.5 mg/kg) treated group and standard drug as glibenclamide (0.65 mg/kg). One hour after test drug administration and vehicle to control group, mice were administered orally with glucose (5g/kg) solution in distilled water and blood glucose level was recorded at 30min, 60min and 120min of post glucose overload. Results: Administration of glucose solution produced highly significant increase in blood glucose level in control group at 30, 60, 90 and 120 mins when compared to its initial blood glucose. Laghu Malini Vasanta Rasa produced statistically highly significant decrease in blood glucose level at 30 min, 60 min and 120 min intervals while non-significant decrease at 90 min interval in comparison to control group. Conclusion: From the present study, it is concluded that Laghu Malini Vasanta Rasa possesses significant antihyperglycemic potential which substantiates its use as an alternative medicine in management of type 2 Diabetes mellitus.

Keywords: Antihyperglycemic effect, Laghu Malini Vasanta Rasa, rejuvenation, Yashada, Zinc.