BIOAVAILABILITY OF A BIOAVAILABLE CURCUMIN IN HEALTHY HUMAN VOLUNTEERS
*Dr. Harish S.
Numerous publications have reported the significant pharmacodynamic activity of Bioavailable Curcumin (k Patel) despite low or undetectable levels in plasma. The objective of the present study was to perform a detailed pharmacokinetic evaluation of Bioavailable Curcumin (k Patel) after the oral administration of a highly Bioavailable lipidic formulation of TURMERIC BIO-AVAILABLE EXTRACT (35%) 500 MG CAPSULE i.e T2 (K PATEL) (95% EXTRACT CURCUMIN i.e. T2 (K PATEL)) in human subjects. The ratio (T2/T1) of Cmax, AUC0-t and AUC0-inf of Curcumin are found as 223.76, 340.14 and 334.48 respectively. The Test product (T2) Turmeric bio-available extract (35%) 500 mg capsule was found relatively bioavailable and almost 3 times superior for Cmax, AUC0-t and AUC0-∞ with the Test Product (T1); Turmeric extract (95%) 500 mg capsule.
Keywords: Curcumin; bioavailability; absorption; pharmacokinetic modelling.
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