FORMULATION AND IN VITRO EVALUATION OF CHRONOTHERAPEUTIC PRESS-COATED TABLETS OF VALSARTAN WITH NATURAL CONTROLLED RELEASED GUMS

*A. Bharathi and D. Chandra Sekhar Naik

ABSTRACT

Chronotherapeutic press-coated tablets are basically time-controlled drug delivery systems in which the system controls the lag time and drug is released in an immediate or extended fashion. The current investigation was conducted to formulation and evaluation of chronotherapeutic press-coated tablets of valsartan for hypertension disease. The compression coated tablets consisted of a core tablet containing drug with natural ocimum gratissimum mucilage a novel superdisintegrant used, which was further press coated by natural controlled time released gums such as Anogeissus Latifolia, Gardenia Gummifera, in varying ratios. After carrying out preformulation studies, the developed tablets were evaluated for post-compression parameters like weight variation, thickness, hardness, friability, drug content and in-vitro drug release study. The best formulation was selected based on post-compression parameters and was subjected to accelerated stability studies for 3 month. Amongst 5 formulations prepared for coating tablets we are F2CC5 produced convincing results with a maximum cumulative drug release of 100.74%. in 9 hr and Also the formulation didn’t show any significant changes during 3 month period of stress testing. By virtue of its release pattern and delivering the drug at the right time, right place and in right amounts, the developed delivery system holds good promises of benefiting the patients suffering from hypertension.

Keywords: Chronotherapeutic, press-coated, valsartan, mucilage, Gardenia Gummifera.