EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CHEMICAL PROFILING OF ANTIMICROBIAL COMPOUNDS FROM STREPTOMYCES SP.

Renu Solanki, Aditi Kundub, Payal Das and Monisha Khanna*

ABSTRACT

Natural products from micro-organisms are an important source of antibiotics against drug resistant pathogenic microbes. Actinomycete genera especially Streptomyces are well known for production of antimicrobial compounds. In the present study, Streptomyces sp. isolated from HCH dump site, Lucknow was subjected to antimicrobial analyses. Structure elucidation of purified bioactive compounds was done by mass spectrometry (MS) and nuclear magnetic resonance (NMR) after their identification by bioautography. It was revealed that compound structures showed partial resemblance to known antibiotic groups indicating tentative presence of novel chemical moieties. One of the compounds from isolate L3.46 extracted in ethyl acetate had molecular weight of 681g/mol similar to mycinamicin III, a macrolide antibiotic. Mass fragmentation pattern of L3.46 compound showed partial resemblance to mycinamicin III. A second bioactive compound isolated from L3.46 extracted in methanol was found to have molecular weight of 771 g/mol. Its core structure showed resemblance to xantholipin, belonging to xanthone group of antibiotics. On the basis of structural studies, compounds were identified as Mycinamicin III and Xantholipin derivatives respectively.

Keywords: Actinomycetes, Antimicrobial compounds, Structure elucidation, Mass spectrometry (MS), Nuclear magnetic resonance (NMR)


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database