EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HEPATOPROTECTIVE ACTIVITY STUDIES OF CUCUMIS TRIGONUS ROXB. AGAINST RIFAMPICIN-ISONIAZID-INDUCED TOXICITY IN RATS.

Subarayan Bothi Gopalakrishnan*, Thangaraj Kalaiarasi

ABSTRACT

The fruits of Cucumis trigonus Roxb. was analysed for the hepatoprotective activity against albino rats with liver damage induced by rifampicin-isoniazid. Rifampicin (RIF) plus isoniazid (INH) treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury. The ethanolic extract of the fruits of Cucumis trigonus showed normalization of body weight, biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase (SALP), γ- glutamyl transpeptidase (GGTP), total bilirubin (TB), total protein (TP) as well as the levels of liver homogenates, Lipid peroxidase (LPO), glutathione peroxidase (GPx), glutathione reductase (GRD), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH). The effects of ethanolic extract of the fruits of Cucumis trigonus (100 mg/kgbw ip 250 mg/kgbw ip & 500 mg/kgbw ip) was compared with that of the standard drug, silymarin. The ethanolic extract showed significant hepatoprotective activity in 500 mg/kg ip dose. The hepatoprotective activity has also been supported by histopathological studies of liver tissue.

Keywords: Hepatoprotective, Cucumis trigonus, Histopathology.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database