A REVIEW ON LIPOSOMES: NOVEL DRUG DELIVERY SYSTEM
Shimge Krishna R., Nagoba Shivappa N.*, Wadulkar R. D. and Sarukh Vikram S.
The all new potential therapeutics has poor pharmacokinetic and biopharmaceutical properties. Hence there is need to develop a suitable drug system that distributes the therapeuticallyactive drug molecule only to site of action, without affecting healthy tissue or organ. Liposomes are spherical shaped microscopic vesicles consisting of lipid bilayer in structure with phospholipids. and cholesterol being the main ingredients. These are superior carrier and have ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. Liposomes are prepared by using various methods hand shaking method,sonication, freeze drying method, ethanol injection method, ether injection method, micro-emulsion method. The different application of liposomes is use for treatment of infection, anti-cancer, vaccination, for human therapy and gene delivery system. After the formulation, the evaluation of liposomes are checked by using physical parameters, chemical parameters, and biologically for the establish the purity and potency of various lipophilic constituents and establish the safety and suitability of formulation for therapeutic application.
Keywords: Liposome, Lipid vesicle, Method of preparation, Evaluation and Applications.
[Full Text Article]