CLINICAL USEFULNESS OF CREATININE AND CYSTATIN C- AN UPDATE
Fredrick Saron, Dhananjayan R., Swaminathan S.*
According to World Health Organization, the number of people affected with kidney failure worldwide is around 10% and annually about one million people die due to untreated kidney disease. The contributing factors for kidney diseases include untreated hypertension and type 2 diabetes mellitus (T2DM). The first line of biomarker to detect kidney failure is the measurement of serum creatinine and the detection of proteins in urine and once both are elevated, the next stage is to measure Creatinine Clearance (Cr-Cl) by using serum and urine creatinine to calculate Glomurelur Filtration Rate (GFR). Recently, Cystatin C (CysC) has emerged as an alternate marker to serum Creatinine (Sr-Cr). The aim of this review article is to bring into focus the merits and demerits of using estimated GFR (eGFR), based on Sr-Cr and CysC values as preliminary to aid clinicians in the diagnosis of Kidney related diseases.
Keywords: Cystatin C, Creatinine, Glomerular Filtration Rate, eGFR, Cr-Cl.
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