A COMPARATIVE STUDY OF THE EFFECT OF SYZYGIUM CUMINI AND WHEAT GRAIN ON THE ANTI-ANXIETY ACTIVITY OF BLONANSERIN

Gautam Nishu and Das Sanjita*

ABSTRACT

Objectives: Blonanserin is frequently used for the treatment of anxiety disease. This study includes the effect of Syzygium cumini and wheat grains on the drug (blonanserin) because the patients mostly take the wheat in their diet in India and other countries and Syzygium cumini is one seasonal fruit with antiaxiety activity. Methods: This is a noble approach to assess the comparative study of the effect of Syzygium cumini and wheat grains on the anti-anxiety activity of blonanserin. The plant extract (200 mg/kg and 400 mg/kg) and the drug (2mg) were used for the evaluation of antianxiety activity using actophotometer, elevated plus maze and Y-maze. Results: Actophotometer, Elevated plus maze, Y-maze apparatus that wheat grain has the better anti-anxiety activity from then the Syzygium cumini but is comparatively less than the blonanserin grain showed, Whereas blonanserin with wheat grain showed significantly higher anti-anxiety activity then blonanserin alone. Conclusions: The present investigation shows that wheat grain can be advised to add to the diet of anxiety patient to improve the efficacy of blonanserin and the patients can also take Syzygium cumini in their diet for better effect.

Keywords: Wheat grain, Syzygium cumini, blonanserin, antianxiety activity.