AN ASSOCIATIVE STUDY OF NON-LIPID RISK FACTORS (HIGH SENSITIVE-CRP, URIC ACID AND THYROID STIMULATING HORMONE) WITH PARAMETERS OF TYPE 2 DIABETES MELLITUS, BLOOD PRESSURE IN METABOLIC SYNDROME

V. Srinivasa Babu*, V. Kalyan Chakravarthy, C. Ramaswamy, S. Srikanth, M. Karthik

ABSTRACT

Background: Metabolic syndrome is the huddle of diseases for atherosclerotic cardiovascular disease (ASCVD) which arises due to excess of plasma glucose, cholesterol, fatty acids, blood pressure and obesity. The role of lipids in the development of MetS had been extensively studied. Some non-lipid factors like hsCRP, uric acid and TSH level also remain elevated in the serum of the MetS patients the correlation of the same with the MetS not fully determined. Aim and Objectives: Hence in this study our aim and objectives was to assess the significance of non-lipid risk factors in determining the severity of MetS with the association of type 2 diabetes and blood pressure parameters. Methods: A total of 450 subjects (211 men and 239 women) aged ≥ 35 years attending the hospital were divided based on the components of MetS as control (CS), Metabolic syndrome (MS) and severe (SMS) MetS groups. Comparative study was done by one way ANOVA and variables with significant associations were included in regression analysis to determine the future prediction with non-lipid risk factors hs-CRP, serum uric acid and TSH as dependent variables. The cardiovascular and T2DM related parameters FPG, HbA1c, serum fasting insulin, HOMA-IR, SBP, DBP, PR were independent variables in this study. Results: All the T2DM and BP variables had highly significant relation (P<0.001) when compared MetS and severe Mets group with control group. In this study, the value of participants HbA1C, PR, FPG, DBP and IR had significant Adjusted OR [3.03 P<0.001; 2.10 P 0.004; 1.86 P 0.033; 0.17, P <0.001 and 0.08, P <0.001 respectively] high positive correlation with the hs-CRP values. It was found that HbA1c, SBP, DBP, FPG and PR had significant predictive AOR [5.829 P<0.001; 2.789 P 0.007; 0.098 P<0.001; 0.383 P 0.008 and 0.543 P 0.053 respectively] in association with Uric acid values. Also, PR, FPG and DBP had significant AOR significance [1.96 P 0.001; 1.41 P <0.001; 1.37 P 0.026 respectively] in association with TSH values. Conclusion: It can be concluded that reducing the above T2DM and cardiovascular variables by various lifestyles or other means can reduce the levels of non-lipid risk factors and thereby arrest susceptibility of the development of MetS and severe MetS.

Keywords: T2DM; HTN; Metabolic syndrome; Non-lipid risks; hs-CRP; Uric acid; TSH.