MORPHOLOGICAL CHARACTERISTICS OF METHODS FOR ASSESSING KI-67 IN INFILTRATING BREAST CANCER

Alimhodzhaeva L.T.*, Zakirova L.T., Nishanov D.A., Khodjaev A.V., Norbekov M.Kh., Nigmanova N.A., Zakhirov N.N.

ABSTRACT

The problem of breast cancer (BC) is relevant for modern oncology, which is associated with a pronounced increase in the incidence of women with this pathology and the search for new ways of treatment, in particular the widespread introduction of cost-effective surgical interventions, new antitumor and hormonal drugs. Historically, breast cancer was considered as a single disease. The development of science allowed us to first isolate hormone-dependent tumors into a separate group, then divide tumors according to HER2 status, and then isolate tumors that have virtually none of the three estrogen receptor markers, progesterone receptors and HER2 receptor overexpression. Depending on the allocation of a particular subgroup of breast cancer, treatment approaches change. The Ki67 marker allows determining the “hidden” proliferative potential of a tumor and judging the degree of malignancy. An indicator of less than 10% - the prediction of survival is 95%. With the result from 10 to 15% - the five-year boundary is successfully overcome by 85% of patients. Norm Ki67 for breast cancer is up to 15%, at which the prognosis is favorable. The purpose of treatment with hormonal drugs is shown. Pr 30%-carcinoma will respond well to chemotherapy. The result of 90% - pronoz unfavorable, the survival rate is almost zero. It has been experimentally proven that with carcinoma sensitivity to hormonal drugs and the absence of secondary lesions in other organs and lymph nodes, but with high Ki67 rates, the likelihood of recurrence is very high. If, at a relapse of the disease, the Ki67 values were higher in the first tumor, then the secondary new formation is more aggressive. Therefore, it will require the appointment of a combined treatment.

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