EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CYANOACRYLATES: AN OVERVIEW IN ITS APPLICATION AS A TISSUE ADHESIVE

Harsha Kathpalia, Vasudha Prabhu* and Shail Modi

ABSTRACT

The wound closure has been a matter of concern for the patients more than the surgery itself. Major reasons include the endless pain and the complications involved in the conventional tissue adhesion methods like sutures, staples, screws, etc. Not only the pain involved in suturing and in removing sutures post healing but also the infections in the sutured wounds along with the cosmetically unacceptable scars are the major reasons for the development of the tissue adhesives and sealants for the wound closure. Tissue adhesives seem to be of great importance since they have the capability of either completely replacing the conventional wound closure technique or at the minimal provide a support for reducing the number of stitches. The ideal dressing should achieve rapid healing at reasonable cost, with minimal inconvenience to the patient. This article offers a review of the emerging technology using cyanoacrylates for achieving improved, painless and patient compliant wound healing. Cyanoacrylates are strong, fast-setting liquid monomers. These upon exposure to moisture start to set due to polymerisation reaction. Fast-setting, high tensile strength, good flexibility, durability, waterproof nature and transparent appearance, are few of the properties which make cyanoacrylates ideal for wound closure and skin barrier products. General formation and formulation approach of cyanoacrylates towards achieving optimum physical properties, mechanism of tissue adhesion and evaluation parameters along with applications, safety assessment, their key advantages and shortcomings are also considered briefly.

Keywords: Cyanoacrylates, Polymerization, Hemostat, Tissue adhesive.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia

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