EFFECT OF BENFOTIAMINE ON THE CORRECTED QT INTERVAL, QT DISPERSION AND SPATIAL QRS-T ANGLE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIAC AUTONOMIC NEUROPATHY

Victoria A. Serhiyenko*, Galina I. Suslyk, Ludmila M. Serhiyenko and Alexandr A. Serhiyenko

ABSTRACT

Background: The significance of cardiac autonomic neuropathy (CAN) has not been fully appreciated and there is no unified treatment algorithm. Aim: To investigate the effects of benfotiamine (BFT) on the corrected QT interval (QTc), QT dispersion (QTd) and spatial QRS-T angle in patients with type 2 diabetes mellitus (T2DM) and CAN. Patients and Methods: 32 patients with T2DM and definite stage of CAN were allocated to two treatment groups: control (n = 15) received standard antihyperglycaemic therapy; group 2 (n = 17) - in addition BFT 300 mg/d for three months. The QTc interval, QTd and spatial QRS-T angle parameters were analyzed. Results: It was found out that BFT contributed to decrease of the QTc, QTd and QRS-T angle. Conclusions: The positive influences of BFT suggests the feasibility of its administration to patients with T2DM and definite stage of CAN. Obtained results suggest that the efficacy of BFT is the result of a direct effect of the BFT on the investigated indexes.

Keywords: Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Benfotiamine, Corrected QT interval, Spatial QRS-T angle.