EVALUATION OF PHARMACOLOGICAL ACTIONS OF DERIVATIVES OF 4- THIAZOLIDIONES AND 1,3,4- THIADIAZOLES
Shail Modi* and Gayatri Aggarwal
The project involves evaluation of pharmacological actions of derivatives of 4-thiazolidinone and 1, 3, 4-
thiadiazoles. The derivatives were investigated for various activities such as inflammation, analgesia and some
CNS activities such as CNS depressant, anti-psychotic and skeletal muscle relaxant activity. In-vitro test like
membrane stabilization and protein denaturation and in-vivo activities such as mice paw edema, cotton pellet
granuloma, forced swim test, locomotor activity were carried out to know the pharmacological activities of the test
drugs. It was concluded that the derivatives had anti-inflammatory and analgesic property without development of
ulcers. They also showed muscle relaxant property and depressant characteristics which could be helpful for
sedation. Further investigations were still required for confirmation of CNS activities.
Keywords: Inflammation, 4-thiazolidione, 1,3,4-thiadiazole, forced swim test, catalepsy.
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