( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Geeta K. Patel and Kaushal V. Patel


A capsule based unit dose dry powder for inhalation of long acting muscarinic antagonist, Glycopyrronium bromide with the device Turbospin® #3 dry powder inhaler was prepared to obtain increased drug deposition in the alveolar absorptive region with a view to treat bronchospasm associated with chronic obstructive pulmonary diseases. The influence of different inhalation grade -lactose monohydrate as carrier on the drug-to-carrier interaction and the performance of lactose-based dry powder inhaler formulations were evaluated. The Glycopyrronium bromide (< 5 m) was incorporated with lactose of different grades and their combinations as carriers to deliver dose using an inhaler device. Solid-state characteristics of the carrier as well as the drug powder were assessed by particle size and distribution measurement. The aerosol behavior of the powder was studied by dispersion using Turbospin® connected to a twin-stage liquid impinger (TSLI) operating at flow rates of 60 Lit/min. Significant differences in aerosol performance of Glycopyrronium bromide measured as fine particle fraction (FPF) from the carriers was observed with different grade inhalation lactose. Specifically, as carrier size increased, FPF decreased. Different weight ratios and different size ranges for the fines with coarse lactose showed significant change for in vitro deposition of the drug from formulation. Primary packaging material like hard gelatin capsule and HPMC capsule influenced the DPI performance during the storage period. Formulation containing 70:30 mixture of respitose SV003 and sorbolac 400 as carrier imparts well disaggregation of drug and higher fine particle fraction was achieved at 60 Lit/min. Thus the object of the present invention is to provide DPI comprise LAMAs, allows highly efficient and sufficient amount of dosing when inhaled by the patients even in a low pressure.

Keywords: Long acting muscarinic antagonist, dry powder inhaler, fine particle fraction, twin-stage liquid impinger, drug-to-carrier interaction.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on


    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )