EFFECT OF AZADIRACHTA INDICA ON THE PHARMACODYNAMICS OF PIOGLITAZONE IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS

Rajasekhara Reddy T.*, Swathi P. and Eswar Kumar K.

ABSTRACT

The objective of the study is to find out the effect of Azadirachta indica on pharmacodynamic interactions with concomitant administration with pioglitazone in both normal and diabetic rats. Blood samples were collected from rats by retro orbital puncture at regular intervals of time 0, 1, 2, 3, 4, 6, 8, 10, 12 hr. During the single dose administration of Pioglitazone and Azadirachta indica showed reduction of blood glucose levels dose dependently. The pioglitazone (10mg/kg) showed peak glucose reduction at 2hr, Azadirachta indica (200mg/kg) at 4hr, the combination at single and multiple dose combinations showed peak glucose reduction at 2hr in both normal and diabetic rats. The insulin levels were also found to be increased according to the blood glucose reduction at peak hours. It indicates that the combination of Azadirachta indica and pioglitazone producing the significant synergistic action in producing hypoglycemia and antihyperglycemia. Hence, care must be taken while prescribing the combination in clinical situation.

Keywords: Pioglitazone, Azadirachta Indica, Blood Glucose, Insulin.