POTENTIAL ACTIVITY OF THE SEEDS OF BALANITES AEGYPTIACA AGAINST IRRITABLE BOWEL SYNDROME AND HEMORRHOID

Aniruddh Pratap Singh* and Sanjita Das

ABSTRACT

Balanites aegyptiaca (Family: Zygophyllaceae) is scientifically proven to have extensive medicinal values. In the present research work an effort has been taken to explore its seeds kernel for the potential activity against croton oil induced hemorrhoid modal in rat and against irritable bowel syndrome induced by acetic acid in rats. The results show that anti-hemorrhoidal and anti-IBS activity of Balanites aegyptiaca seed kernel extract at the dose of 100 and 200 mg/kg body weight was comparable with anti-hemorrhoidal activity of standard drug treatment 20 mg/kg body weight of hydrocortisone. For IBS the intestinal movement of rat ileum given by 10% solution of seed extracts was compared with standard drug 0.01mg/ml atropine solution. The data also supplement for severity score, Recto anal coefficient and histopathological study of rectoanal tissue section of rat. Antihemorrhoidal and anti-IBS activity of seed kernel extract of Balanites aegyptiaca showed significant p value of, P≤ 0.01 and P≤ 0.01.

Keywords: Balanites aegyptiaca, Irritable bowel syndrome, hemorrhoid.