EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

COMPARATIVE EVALUATION OF EFFICACY OF PALLIATIVE RADIATION THERAPY WITH DEXAMETHASONE VERSUS PALLIATIVE RADIATION THERAPY ALONE FOR PAIN FLARES IN PAINFUL BONE METASTASIS

Sunder Singh, Rakesh Dhankhar, Kiran Dahiya*, Keerti Gupta, Sanghapriya Pal and Anil Khurana

ABSTRACT

Development of pain flares is a common association with palliative radiotherapy for management of bone metastasis. Dexamethasone, a hydrocortisone with anti-inflammatory property, holds a potential for prevention of pain flare in these patients when used as an adjuvant therapy. The study was conducted on 60 patients divided randomly into 2 groups of 30 patients each. Group I patients received palliative external radiation therapy 20 Gy in 5 fractions for 5 days with tablet dexamethasone 8mg orally one to five days while group II patients received palliative radiation therapy only. All the patients were followed every day for 5 days and then monthly for 6 months for occurrence of pain flare. Group I patients were observed to have reduced pain flare (p<0.05), less requirement of analgesics (p<0.05), overall better pain relief (p<0.05) and lesser need of re-irradiation as compared to those in group II. Thus, dexamethasone may be used as an adjuvant to standard palliative radiotherapy for the management of painful bone metastasis though the claim is still debated and needs substantiation with more supportive studies.

Keywords: Pain flare, Dexamethasone, Palliative Radiotherapy, Painful bone metastasis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia