FORMULATION AND CHARACTERISATION OF SUSTAINED RELEASE MATRIX TABLETS OF ATAZANAVIR

Bharathi A.*, S. Durga Saranya, J. Sushma Roj, Chandra Sekhar Naik and Madhavi Kiran S.

ABSTRACT

The objective of present study is to develop a pharmaceutically stable sustained release matrix tablets of Atazanavir and perform the pre compression and post compression parameters and also in-vitro evaluation studies of developed formulation. In this investigation the sustained release matrix tablets of Atazanavir were prepared by direct compression method using different polymers like Guar gum, Xanthan gum and Sodium alginate in various concentrations. All the formulations showed acceptable pharmacopiea standards. In this investigation formulation F8 have extended the drug release upto 12hrs. Model fitting analysis for formulation F8 fitted in the zero order, first order, higuchi and peppas plots. The n values obtained from peppa’s equation suggested that drug release was followed by non fickaiann diffusion mechanism. Successful formulation was found stable after evaluation for all parameters when kept for 30 days at room temperature at 400c.

Keywords: Atazanavir, Sustained Release Tablets.