EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SLEEP DURATION ENHANCEMENT: EFFECTS OF MAGNESIUM SULFATE DERMAL SPRAY IN A NORMAL PERSON

*Chu J., Bruyninckx F. and Neuhauser D. V.

ABSTRACT

Importance: Sleep deprivation or prolonged sleep has significant deleterious health effects on the cardiovascular system related to disturbances in autonomic nervous system (ANS) function. Magnesium sulfate (MgSO4) is an inexpensive natural element which reduces blood pressure (BP) through its effects on ANS and its probable influence on sleep duration with transdermal application, needs scientific recognition. Objective: To document that MgSO4 dermal spray can extend sleep duration safely and efficaciously by its transdermal effects on the ANS. Design, Setting, and Participants: Single person statistically-controlled data of the corresponding author. Home setting. Main Outcomes and Measures: Self-measurement of systolic (S), diastolic (D) BP and H-R before sleep and on immediate awakening the following morning during the control phase of regular sleep (N=54). During the test phase (N=48) BP/H-R were immediately measured pre-sleep (before spraying MgSO4) and on immediate awakening the following morning. Results: Sleep duration 420 minutes sleep in 13% and 79% of occasions. Significantly higher SBP, DBP, and H-R noted post regular sleep. Post MgSO4 aided-sleep had similar BP findings but without significant changes in H-R. With increasing sleep durations, natural sleep had a significant increase in SBP and H-R but MgSO4 spray aided-sleep showed a significant decrease in SBP and DBP without significant H-R changes. Conclusions and Relevance: Transdermal application of MgSO4 spray definitively increases sleep duration safely and efficaciously. Any interested person can self-investigate the deleterious cardiovascular health effects of curtailed/prolonged sleep by daily self-recording sleep duration, BP and H-R pre- sleep and on-awakening the following morning.

Keywords: Sleep duration enhancement; magnesium sulfate dermal spray ; self-detect ; cardiovascular health ; blood pressure; heart-rate.

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