( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Chu J., Bruyninckx F. and Neuhauser D. V.


Importance: Sleep deprivation or prolonged sleep has significant deleterious health effects on the cardiovascular system related to disturbances in autonomic nervous system (ANS) function. Magnesium sulfate (MgSO4) is an inexpensive natural element which reduces blood pressure (BP) through its effects on ANS and its probable influence on sleep duration with transdermal application, needs scientific recognition. Objective: To document that MgSO4 dermal spray can extend sleep duration safely and efficaciously by its transdermal effects on the ANS. Design, Setting, and Participants: Single person statistically-controlled data of the corresponding author. Home setting. Main Outcomes and Measures: Self-measurement of systolic (S), diastolic (D) BP and H-R before sleep and on immediate awakening the following morning during the control phase of regular sleep (N=54). During the test phase (N=48) BP/H-R were immediately measured pre-sleep (before spraying MgSO4) and on immediate awakening the following morning. Results: Sleep duration 420 minutes sleep in 13% and 79% of occasions. Significantly higher SBP, DBP, and H-R noted post regular sleep. Post MgSO4 aided-sleep had similar BP findings but without significant changes in H-R. With increasing sleep durations, natural sleep had a significant increase in SBP and H-R but MgSO4 spray aided-sleep showed a significant decrease in SBP and DBP without significant H-R changes. Conclusions and Relevance: Transdermal application of MgSO4 spray definitively increases sleep duration safely and efficaciously. Any interested person can self-investigate the deleterious cardiovascular health effects of curtailed/prolonged sleep by daily self-recording sleep duration, BP and H-R pre- sleep and on-awakening the following morning.

Keywords: Sleep duration enhancement; magnesium sulfate dermal spray ; self-detect ; cardiovascular health ; blood pressure; heart-rate.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on


    NOVEMBER Issue has been successfully launched on 1 November 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )