COMPARATIVE EFFECT OF ANTIDIABETIC DRUG SITAGLIPTIN WITH SZYGIUM CUMINI ON PANCREATIC ACTIVITY

Sonia Khan, Noor Jahan*, Muhammad Mujtaba Ali, Mehjabeen, Farah Owais and Saleem Khanzada

ABSTRACT

Many oral hypoglycemic drugs are available for the treatment of diabetes mellitus. Along with other hypoglycemics dipeptidylpeptidase-4 inhibitors that is Sitagliptins are one of the new drugs which are used for the treatment of diabetes. The DPP4 inhibitors are gliptins that are used orally. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP) which inhibit glucagon release, which in turn increases insulin secretion. Sitagliptin may cause pancreatitis and infections so the combination of Sitagliptin and S. cumini can be helpful to reduce dose of Sitagliptin and can increase safety and efficacy of Sitagliptin. The seeds of Jamun used as antidiabetic agent. Szygium cumini belongs to family Myrtaceae. It is commonly known as Jambol fruit and locally as Jamun. Results showed that combination has synergistic hypoglycemic activity. Sitagliptin not produced severe pancreatitis and with the combination it gives more improved activity. C-reactive protein and serum lipase levels not altered significantly. Serum amylase level reduced with combination so it can increase protection against pancreatitis.

Keywords: DPP-4 inhibitors, sitagliptin, Szygium cumini, antidiabetic, pancreatitis.