THE HISTO-PROTECTIVE EFFECTS OF THE ROOT EXTRACTS OF SALACIA NITIDA BENTH ON TISSUES OF ALLOXAN INDUCED DIABETIC RATS

Zawua C. Irene*, H. D. Kagbo and B. D. Dooka

ABSTRACT

Aim: This study was carried out to determine the histo-protective and regenerative effects seen on the liver, tissue and pancreas in alloxan induced diabetic rats after administration of Salacia nitida Benth. Study design: Experimental Animal Study. Place and Duration of Study: Department of Pharmacology, University of Port Harcourt, Rivers State from July 2016 to February 2017. Methodology: This study was carried out to investigate the potential tissue protective effects of the root extracts of Salacia nitida Benth in alloxan induced diabetic rats. Fifty five adult Wistar rats randomly divided into eleven groups of five rats each. The method of successive extraction was used. The anti-diabetic study was evaluated in twenty-one days, comprising of two phases: induction phase and treatment phase. On day 21 of treatment with S. nitida extracts, the animals were sacrificed and histological analysis carried out. Results: the histolgical examination of the kidney, liver and pancreas of alloxan induced diabetic rats indicated a protective effect after administration of the dicholoromethane extract with less diabetes induced degenerative damage seen. Conclusion: the dicholoromethane extract showed histoprotective effects as seen with the regeneration of damaged cells on exposure of the rats to alloxan.

Keywords: Alloxan, Salacia nitida, histology, blood glucose, type I, type II.