ENHANCED ORAL BIOAVAILABILITY OF RAMIPRIL BY SELF EMULSIFYING LIPID DELIVERY SYSTEM

*Saket Bhasin and Ritesh B. Patel

ABSTRACT

To enhance the solubility and bioavailability of poorly water-soluble Ramipril self-emulsifying lipid delivery system (SEDDS) composed of oil, surfactant and cosurfactant for oral administration was formulated. The solubility of ramipril was determined in various oils and surfactants & co-surfactants. The optimized SEDDS formulation consists of sunflower oil, caprylocaproyl macrogol-8 glycerides & glyceryl monocaprylate was selected basis the ternary phase diagram studies.This formulation were evaluated for visual characters, emulsification time, particle size & charge of dispersed emulsion, drug release profile & physic-chemical initial & accelerated stability. Ternary phase diagrams were used to evaluate the emulsification domain. The pharmacokinetic study in rats for the optimized formulation was performed and compared against marketed product. SEDDS have significantly increased the Cmax and area under the curve (AUC) of ramipril and reduced Tmax compared to marketed tablet formulation (P < 0.05). Thus, this self-micro emulsifying drug delivery system should be an effective oral dosage form for improving oral bioavailability of ramipril.

Keywords: Ramipril, Self-emulsifying lipid delivery system, Solubility, Bioavailability.