EVALUATION OF EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CARCINOMA
Anjali Sindhu, Swaran Kaur, Parveen Rana Kundu, Ruchi Agarwal, Yudhvir Singh, Prerna Mahajan
Objective: Cyclin D1 over expression may be one of the several mechanisms involved in endometrial neoplasia.
The present study was undertaken to examine the expression of Cyclin D1 in endometrial hyperplasia and
carcinoma. Materials and Methods: A cross sectional study was conducted over a period of 1 year. We evaluated
and compared the expression profile of Cyclin D1 in 60endometrial samples that were diagnosed as simple
hyperplasia (n=24), complex hyperplasia (n=12) and endometrial carcinoma (n=24). Results: An increasing
expression of Cyclin D1 was seen from simple hyperplasia to carcinoma endometrium. Moreover, complex
hyperplasia showed the maximum positivity for Cyclin D1. Conclusion: Cyclin D1 overexpression is an early
event in development of endometrial neoplasia. Also maximum deregulation occurs at the stage of complex
hyperplasia. Both simple and complex hyperplasia need to be followed up closely due to their premalignant
Keywords: Endometrial carcinoma, cyclin D1, simple hyperplasia, complex hyperplasia.
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