EVALUATION OF EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CARCINOMA

Anjali Sindhu, Swaran Kaur, Parveen Rana Kundu, Ruchi Agarwal, Yudhvir Singh, Prerna Mahajan

ABSTRACT

Objective: Cyclin D1 over expression may be one of the several mechanisms involved in endometrial neoplasia. The present study was undertaken to examine the expression of Cyclin D1 in endometrial hyperplasia and carcinoma. Materials and Methods: A cross sectional study was conducted over a period of 1 year. We evaluated and compared the expression profile of Cyclin D1 in 60endometrial samples that were diagnosed as simple hyperplasia (n=24), complex hyperplasia (n=12) and endometrial carcinoma (n=24). Results: An increasing expression of Cyclin D1 was seen from simple hyperplasia to carcinoma endometrium. Moreover, complex hyperplasia showed the maximum positivity for Cyclin D1. Conclusion: Cyclin D1 overexpression is an early event in development of endometrial neoplasia. Also maximum deregulation occurs at the stage of complex hyperplasia. Both simple and complex hyperplasia need to be followed up closely due to their premalignant potential.

Keywords: Endometrial carcinoma, cyclin D1, simple hyperplasia, complex hyperplasia.