EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database ,

ISSN 2394-3211

Impact Factor: 6.222

ICV - 79.57

Abstract

EVALUATION OF EXPRESSION OF CYCLIN D1 IN ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CARCINOMA

Anjali Sindhu, Swaran Kaur, Parveen Rana Kundu, Ruchi Agarwal, Yudhvir Singh, Prerna Mahajan

ABSTRACT

Objective: Cyclin D1 over expression may be one of the several mechanisms involved in endometrial neoplasia. The present study was undertaken to examine the expression of Cyclin D1 in endometrial hyperplasia and carcinoma. Materials and Methods: A cross sectional study was conducted over a period of 1 year. We evaluated and compared the expression profile of Cyclin D1 in 60endometrial samples that were diagnosed as simple hyperplasia (n=24), complex hyperplasia (n=12) and endometrial carcinoma (n=24). Results: An increasing expression of Cyclin D1 was seen from simple hyperplasia to carcinoma endometrium. Moreover, complex hyperplasia showed the maximum positivity for Cyclin D1. Conclusion: Cyclin D1 overexpression is an early event in development of endometrial neoplasia. Also maximum deregulation occurs at the stage of complex hyperplasia. Both simple and complex hyperplasia need to be followed up closely due to their premalignant potential.

Keywords: Endometrial carcinoma, cyclin D1, simple hyperplasia, complex hyperplasia.

[Full Text Article]

SJIF Impact Factor: 6.222

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NEWS & UPDATION

New Issue Published
Its Our pleasure to inform you that, EJPMR 1 November 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR: NOVEMBER ISSUE PUBLISHED
November issue has been successfully launched on 1 November 2023

EJPMR New Impact Factor
Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 5.804 to 6.222, due to high quality Publication at International Level