EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECTS OF ETHANOLIC EXTRACT OF CYPERUS ESCULENTUS (TIGER NUT) ON SOME LIVER FUNCTION PARAMETERS USING ALBINO WISTAR RATS

Akpojotor Peter*, Njoku Bestman and Kyrian Uchenna Nwoke

ABSTRACT

This study investigates the effects of ethanolic extract of Cyperus esculentus on some liver function parameters. Thirty six albino wistar rats weighing between 180g and 220g were randomly grouped into three (two test groups and a control group) of 12 rats each. After two weeks of acclimatization, Groups 2 and 3 (test groups) were orally administered with 800mg/kg and 400mg/kg of the ethanolic extract of Cyperus esculentus respectively for twenty eight days while group 1 (control group). Were allowed asses to water and feed. After every seven days of extract administration, three rats from each group were sacrificed and blood samples were collected by cardiac puncture for biochemical analysis of some liver enzymes (alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST), serum total protein and serum albumin). Livers of the sacrificed animals were also harvested for histological studies. Data obtained from the study were analyzed statistically. Result showed a dose dependent significant (P<0.05) increase in serum concentration of ALT and ALP. Serum concentration of total protein, albumin and AST were not overtly affected. The histological study of the harvested liver showed hepatocytes degeneration and periportal inflammations indicating alteration in the normal physiological status of the liver. Findings from this study showed that the extract could be unhealthy to the liver; hence care should be taken when consuming the fruit.

Keywords: Cyperus esculentus, liver enzymes, hepatocytes and inflammation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )