EVALUATION OF ANTI ANAEMIC ACTIVITY OF AQUEOUS PIPER BETLE LEAF EXTRACT AGAINST PHENYL HYDRAZINE INDUCED ANAEMIA IN WISTAR RATS
Sara Lavanya, Dr. Konda Swathi, Dr. Veeresh Babu, Srivani*, Dr. Ananta S. Metlakunta, B. Manish Goud*
The aim of the present study was to investigate the anti-anaemic activity of aqueous leaf extract of Piper betle against Phenyl hydrazine induced haemolytic anaemia in Wistar rats. Hemolytic anaemia was induced by intraperitoneal administration of phenyl hydrazine at a dose of 40 mg/kg for 2 consecutive days. Anaemic rats were orally treated with aqueous extract of Piper betel at doses of 250, 1000 & 2000 mg/kg/day. The rats were analyzed for hematological parameters such as Hb, RBC and hematocrit on day 0, 2 and 21.The aqueous extract significantly increased the RBC, Hb, Hematocrit levels which conclude that it exhibits anti-anaemic activity. This study revealed antianemic activity of aqueous extract of Piper betle, thus confirming the traditional use of this plant in anemia treatment.
Keywords: Anaemia, Hematological Parameters, Phenylhydrazine, Piper Betle, Hematological Parameters.
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