THYROID DYSFUNCTION IN LIBYAN CHILDREN WITH DOWN SYNDROME
*Dr. Najwa. H. Abduljawad and Dr. Ibtisam Hadeed
Background: Down syndrome (DS) is the most common chromosomal abnormality observed in live born infants.
Individuals with DS exhibit a wide range of thyroid dysfunction. In this study, we aimed to document the range of
thyroid function in a cohort of Libyan children with DS. Patients & Methods: Observational descriptive study
were conducted at 2 centers in Libya (Tripoli Medical Centre, and Al-Thawra hospital) between (2011 – 2018).
183 Libyan children with down syndrome (DS) who were admitted to pediatric department of the 2 centers.
Information on age, gender, maternal age at childbirth, presence of congenital anomalies, family history of thyroid
disorders, and complete TFTs were obtained and others associated disorder. Results: 183 children with DS were
participated in the current study, aged between [5 days – 16 years], there was a slight female predominance (55%).
Of the total of 183 DS children, TFTs were normal in 107 children (58%), and were found to be abnormal. In 76
(42%). (30%) have overt thyroid diseases. Overt thyroid diseases including CH (1%), acquired hypothyroidism
83%), and hyperthyroidism (4%), while SCH was found in more than two third of cases (70%) or (53 out of 76
cases). Of 53 cases with SCH, 35 cases showed a spontaneous decrease of TSH to normal level, 10 patients showed
persistently elevated TSH level, and thyroxin therapy was started for them, while 8 cases showed fluctuation in
TSH level. Conclusion: Thyroid dysfunction is common among Libyan children with DS. SCH represented more
than two-third of the thyroid dysfunction in this study. No significant correlation have seen in this study between
thyroid dysfunction in children with DS and the presence of congenital anomalies as well as no significant
correlation between thyroid dysfunction in DS children and maternal age, in contrast; we have observed a highly
significant correlation between thyroid dysfunction in DS children and positive family history of thyroid
Keywords: Children with DS, Thyroid dysfunction, hypothyroidism, SCH, CH.
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