HEPATOTHERAPEUTIC POTENTIALS OF SIDA CORYMBOSA (WIRE WEED) ETHANOLIC LEAF EXTRACT ON CARBON TETRACHLORIDE (CCL4)-INDUCED ACUTE HEPATOTOXICITY ON MALE ALBINO WISTAR RATS

Charles Chijioke Dike*, Francis Chukwuemeka Ezeonu, Hugh Clifford Chima Maduka, Ezeokafor Emmanuel Nonso and Oguazu Chinenye Enoch

ABSTRACT

Aim: This work aimed at evaluating the hepatotherapeutic potentials of Sida corymbosa ethanolic leaf extract against carbon tetrachloride (CCL4)-induced hepatotoxicity on male Albino Wistar rats. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphate (ALP) were determined spectrophotometrically. Body and liver weights were measured using electronic weighing balance, while water consumption was measured using calibrated water bottle. Histopathological examination was carried out using hematoxyline and eosine (H and E) staining technique. Results were analyzed using ANOVA, using SPSS statistical software (version 21). The liver function (Serum AST, ALT, and ALP) assays carried out revealed significant decrease (P<0.05) in the levels of serum AST, ALT and ALP in groups of rats administered 5000, 3000 and 1000 mg/kgbw of the extract after inducing hepatotoxicity using CCL4 against groups induced hepatotoxicity without given any treatment from seven days to twenty eight days which had. These are suggesting that the treated rats with the extract may be recovering from the hepatic injury. The above changes were greatest in those administered the extract at 5000 mg/kgbw for 28 days. This suggests dose and time dependent effect. The treatment also showed positive effects on body weights and water consumption of the treated rats. The above findings were confirmed by the histological examination carried out. Sida corymbosa ethanolic leaf extract may therefore has some therapeutic effects on the livers of male Albino Wistar rats damaged by CCL4 toxicity.

Keywords: Hepatic injury, Liver functions, sida extract.