SYNTHESIS OF NEWLY SUBSTITUTED PYRAZOLE DERIVATIVE AND THEIR ANTIINFLAMMATORY ACTIVITY

*Dr. Indu Singh

ABSTRACT

A series of novel pyrazole derivatives have been synthesized by the reaction of substituted chalcones with phenylhydrazine. The starting materials were prepared by reaction of acetophenone with substituted aldehydes in presence of sodium hydroxide. The structure of newly synthesized compounds has been characterized by using elemental analysis and IR and 1HNMR spectral analysis. The melting points of synthesized compounds were determined in open capillaries with the help of thermonic melting point apparatus and the homogeneity of newly synthesized compounds was checked by TLC. The synthesized compounds have been evaluated to determine their anti-inflammatory activity. The anti-inflammatory activity of synthesized compounds was compared by phenylbutazone. In this series compound 2j showed better anti-inflammatory activity than standard drug.

Keywords: Pyrazole, anti-inflammatory activity, phenylbutazone.