EFFECT OF ADD ON SUBLINGUAL VITAMIN D3 ON SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN PATIENTS OF HYPERTENSION ON ANTIHYPERTENSIVE TREATMENT
Sanjeeva Kumar Goud T.*, Dr. Rahul Kunkulol and Dr. Sandeep Narwane
Introduction: The aim of present study was to study effects of Sublingual Vitamin D3 on blood pressure of
hypertensive patients on antihypertensive drugs. Methods: This study was Non-Randomized Clinical Trail, in
which 110 Hypertensive Patients participated in the study, of which, 55 each were enrolled in Test and Control
Group each. All the hypertensive patients visiting the Medicine OPD of Pravara Rural Hospital, Loni, of age
between 18-60 years and either gender, willing to participate in study were included in the study. Patients on
thiazide diuretics or on any other chronic medications other than antihypertensives were excluded from the study.
After taking written informed consent of the study participants, the patients were assigned into Test group and
Control group. The participants in the test group were given add on therapy of Sublingual vitamin D3 60,000IU
every 15 days for 3 months and their blood pressure was measured. Results: There was statistically significant
difference reduction in systolic blood pressure from baseline visit (134±13 mm of Hg) in comparison with Visit II,
V, VI and VII (ANOVA with post hoc Tukey test). Also, there was significant reduction in systolic blood pressure
when Visit II, III, and IV were compared with Visit VII. Statistically significant difference was seen on comparison
of systolic blood pressure of participant in Test group with that of Control group during Visits II (P<0.05, Unpaired
t test), IV, V, VI and VII (P<0.05, Mann-Whitney Test). Conclusion: Sublingual Vitamin D3 therapy causes
average fall in systolic blood pressure of 15 mm of Hg. Sublingual Vitamin D3 may have an add on therapeutic
role in treatment of hypertension.
Keywords: Sublingual Vitamin D3,Blood pressure,Hypertensive patients.
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