FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE MICROSPHERE FOR AN ALPHA GLUCOSIDASE INHIBITOR

K. Jesindha Beyatricks*, Agilandeswari D, Piyali Dey, Mohan Maruga Raja, Preethi S, Tincy V

ABSTRACT

The aim of this study was to formulate and evaluate the release of Mucoadhesive Microsphere of Miglitol which is having the half life around 2 hours for the treatment of diabetes type 2 by combine the potential advantages of Mucoadhesive with controlled drug delivery using various ratio of different polymers. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Miglitol microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymers used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-903μm and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Miglitol using sodium alginate along with Carbopol934 as copolymer adhered to the mucus to a greater extent than the microspheres of Miglitol using sodium alginate along with Carbopol 971 and HPMC K4M as copolymers. Analysis of drug release mechanism showed that the drug release from the formulations followed non-Fickian diffusion and the best fit model was found to be Korsmeyer-Peppas. Based on the results of evaluation tests formulation coded T4 was concluded as best formulation.

Keywords: Miglitol. Mucoadhesive. Ionic gelation technique. Sodium alginate. Carbopol.