EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EFFECT OF ORGANIC NITROGEN SOURCE FOR PRODUCTION OF FIBRINOLYTIC ENZYME AS A “CLOT BUSTING DRUG BY ASPERGILLUS JAPONICUM

Saroj Yadav* and Siddalingeshwara K. G.

ABSTRACT

Cardiovascular disease (CVDs) is caused by disorders of the heart and blood vessels, and includes coronary heart disease (heart attacks), cerebrovascular disease (stroke), raised blood pressure (hypertension), peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure. Fibrinolytic enzymes are agents that dissolve fibrin clots extracted from microbes were considered to be a potential thrombolytic agent for the treatment of clot-dissolving in the cases of Myocardial infarction. The fungal strains i.e Aspergillus japonicum KGSY 05 were isolated from different soils from different regions of Karnataka and screened for fibrinolytic activity by plate assay. The potential strain Aspergillus japonicum KGSY 05 were used for the enhance the biosynthesis of fibrinolytic enzyme by supplementation of nitrogen (organic) sources in range of 0.25% to 1.25%. The different organic nitrogen sources such as yeast extract, beef extract and peptone were employed. The peptone showed better yield of 123 IU fibrinolytic enzyme production and yeast extract (1.0%) 68 IU, beef extract (1.0%) 103 IU.

Keywords: Clot buster drug, fibrin carbon source, Aspergillus tamari.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia